Staying alive: defensive strategies in the BCL-2 family playbook.

Staying alive: T cell costimulation, CD28, and Bcl-xL.

Born to be Alive: A Role for the BCL-2 Family in Melanoma Tumor Cell Survival, Apoptosis, and Treatment

The global incidence of melanoma has dramatically increased during the recent decades, yet the advancement of primary and adjuvant therapies has not kept a similar pace. The development of melanoma is often centered on cellular signaling that hyper-activates survival pathways, while inducing a concomitant blockade to cell death. Aberrations in cell death signaling not only promote tumor surviva...

The effects of nitric oxide production blockage by aminoguanidine on passive avoidance memory and expression of Bcl-2 family genes in diabetic rats

Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...

The Language and Culture of a Dream: A Case Study

This study has analyzed the culture and language of the American Dream in Blue Surge. It shows the effects of the formula of success and the competition presented by this dream; and, how it produces neurotic individuals trying to cope with the competitive society by means of neurotic strategies. This study has used Karen Horney’s theories and strategies. Horney says neurosis is engende...

Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species

Although Bcl-2 family proteins were originally identified as key regulators of apoptosis, an impressive body of evidence has shown that pro-survival members of the Bcl-2 family, including Bcl-2, Bcl-XL, and Bcl-w, can also promote cell migration, invasion, and cancer metastasis. Interestingly, cell invasion was recently found to be suppressed by multidomain pro-apoptotic members of the Bcl-2 fa...